Low back pain and incontinence.

摘要

A 29-year-old man presented in June 2005 with a 2-week history of low back pain, progressive lower limb weakness, difficulty initiating micturition and, most distressing, urinary and faecal incontinence. A diagnosis of acute myeloid leukaemia (AML), French-American-British classification, M2, with the chromosomal translocation t(S:21), had been made in July 2003. He was treated with combination chemotherapy with cytarabine and idarubi-cin and achieved complete remission. He subsequently received four cycles of high-dose cytarabine as consolidation chemotherapy and further allogeneic peripheral blood stem cell transplantation due to early relapse in August 2004. He had no signs of relapse and had a good performance status (ECOG grade 0-1) prior to this presentation. Physical examination disclosed local tenderness over the lumbar spine, decreased muscle power in both lower limbs (three of six), perineal anaesthesia and poor anal sphincter tone.