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首页> 外文期刊>Brain research. Molecular brain research >Cloning of mouse Ca(2+)/calmodulin-dependent protein kinase kinase beta (CaMKKbeta) and characterization of CaMKKbeta and CaMKKalpha distribution in the adult mouse brain.
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Cloning of mouse Ca(2+)/calmodulin-dependent protein kinase kinase beta (CaMKKbeta) and characterization of CaMKKbeta and CaMKKalpha distribution in the adult mouse brain.

机译:小鼠Ca(2 +)/钙调蛋白依赖性蛋白激酶激酶β(CaMKKbeta)的克隆以及成年小鼠脑中CaMKKbeta和CaMKKalpha分布的表征。

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摘要

The Ca(2+)/calmodulin-dependent protein kinase kinases alpha and beta (CaMKKs alpha and beta) are novel members of the CaM kinase family. The CaMKKbeta was cloned from mouse brain. The deduced amino acid sequence shared 96.43% homology with the rat CaMKKbeta. Both the alpha and beta isoforms were widely distributed throughout the adult mouse brain. Additionally, all peripheral tissues examined displayed CaMKK alpha and beta expression.
机译:Ca(2 +)/钙调蛋白依赖性蛋白激酶激酶alpha和beta(CaMKKs alpha和beta)是CaM激酶家族的新成员。 CaMKKbeta是从小鼠大脑克隆的。推导的氨基酸序列与大鼠CaMKKbeta具有96.43%的同源性。 α和β亚型都广泛分布在整个成年小鼠的大脑中。此外,检查的所有外周组织均显示CaMKKα和β表达。

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