Regioselectivity in 2-X-pyrazine aminations by O-mesitylenesulfonylhydroxylamine

摘要

The regioselectivity of 2-X-pyrazine aminations by O-mesitylenesulfonylhydroxylamine was studied experimentally and the results are discussed from the viewpoint of electronic and steric factors. DFT calculations are consistent with the reaction proceeding according to an S_N2 mechanism.