Regioselective preparation of 4-chloro-2-thiophencarboxylic acid (REGIOSELECTIVE SYNTHESIS OF 4-CHLORO-2-THIOPHENECARBOXYLIC ACID)

摘要

4-Chloro-2-thiophenecarboxylic acid is prepared by forming a compound of formula (Ia), converting this compound to a compound of formula (IVa), and removing the silyl group R ₃ Si-. The product is useful as an intermediate compound for the preparation of a medicament.