Design, synthesis and pharmacological evaluation of 1,3,4-oxadizole derivatives of aryl acetic acid as anti-inflammatory and analgesic agents

摘要

A series of substituted 1,3,4-oxadiazole derivatives 2a-e and 4a-e have been synthesized from diphenyl acetic acid hydrazide under various reaction conditions. These compounds have been tested in-vivo for their anti-inflammatory and analgesic activities. The compound 2-[(5-diphenylmethyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(3-chloro-4-fluro-phenyl)-acetamide 4b has emerged as the most active compound of the series, and is found to be moderately more potent than standard drug ibuprofen.