Design, Synthesis and evaluation of novel 1,3,4-thiadiazole derivatives as potent anticonvulsant agents with lesser neurotoxicity.

摘要

A new series of 1,3,4-thiadiazole were synthesized starting from 8-hydroxy-quinoline. Structures of the synthesized compounds were confirmed by the use of spectral data (UV, IR, H'NIvIR, C13NMR, Mass) and elemental analysis. All compounds were evaluated for their anticonvulsant activity in four animal models of seizures, viz. Maximal electroshock seizure (MES), subcutaneous pentylenetetrazole (scPTZ), subcutaneous strychnine (scSTY), and subcutaneous picrotoxin (scPIC) - induced seizure threshold tests. The compounds were also evaluated for neurotoxicity. Compounds exhibited anticonvulsant activity in all the four animal models of seizure.