Synthesis of amide derivatives of quinolone and their antimicrobial studies

摘要

A series of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[chloro/1-piperaziny 1/4-methyl-1-piperazinyl/4-ethyl-1-pipera-zinyl/ 4-hydroxyethyl-1-piperazinyl/imidazolyl/morpholinyl]-3 [N-(substituted phenyl amino) carbonyl]quinoline 5-11a-j have been prepared by using substituted arylamine at C-3 position and 1-piperazine/4-methyl-1-piperazine/4-ethyl-1-piperazine/4-hydroxyethyl-1-piperazine/imidazole/morpholine at C-7 position of newly synthesized quinolone 3.Biological profile like antibacterial activity against four different strain viz.S.aureus and B.subtilis (gram-positive bacteria) and E.coli and P.aeruginosa (gram-negative bacteria) and C.albicans (fungi) by cup plate method have been studied.