Synthesis and biological evaluation of novel N1-decyl and C7-sec amine substituted fluoroquinolones as antitubercular and anticancer agents

摘要

A series of novel N1-decyl and C7- sec amine substituted fluoroquinolone derivatives have been synthesized and evaluated for in vitro antitubercular activity against Mycobacterium tuberculosis H(37)Rv strain and anticancer activity have been studied against four human cancer cell lines (HeLa, MDA-MB-231, MIA PaCa and IMR32). Compounds 4 and 5a exhibit significant antitubercular and antiproliferative activity. The results are encouraging and indicate towards a lead molecule in a combination therapy.