Synthesis of some pyrazmo,pyrimido and mercaptopyrimido annelated carbazoles using 2-hydroxymethylene-1 -oxo-1,2,3,4-tetrahydrocarbazoles

摘要

Treatment of 1-oxo-2-hydroxymethylene-1,2,3,4-tetrahydrocarbazole 1 with hydrazine hydrate,hydroxylamine hydrochloride,urea and thiourea in the presence of gl.acetic acid afforded the novel carbazole derivatives namely 4,5-dihydro-2H-pyrazino [3,4-a]carbazoles 2,2-cyano-1-hydroxycarbazoles 3,2,4-dihydroxy-1,4,5,6-tetrahydro-pyrimido[4,5-a]carbazoles 4 and 4-hydroxy-2-mercapto-1,4,5,6-tetrahydropyrimido- [4,5-a]carbazoles 5 respectively.