Synthesis of 1,5-benzothiazepines:Part XXX-Synthesis and antimicrobial studies of 10-substituted-6a,7-dihydro-6H-7-(4-fluorophenyl)-6-phenyl [1] benzopyrano [3,4-c] [1,5] benzothiazepines

摘要

Flavindogenide,3-(4-fluorobenzylidene)-flavanone has been reacted with six 5-substituted-2-aminobenzenethiols,the substituents being halogens as fluoro,chloro bromo,alkyl as methyl and alkoxyl as methoxyl and ethoxyl,to obtain a series of six new compounds,10-substituted-6a,7-dihydro-6H-7-(4-fluorophenyl)-6-phenyl[1] benzopyrano[3,4-c][1,5]benzo-thiazepines 3a-f.The products are characterized on the basis of microanalytical data for elements and IR,~1H NMR,~(19)F NMR and mass spectral studies.All the synthesized compounds have been evaluated for their antimicrobial activity against the bacteria Escherichia coli and GFC (Alteromonas tetraodonis-a new Gram-negative bacteria family) and fungi,Aspergillus niger,A.flavus and Curvularia lunata.All the compounds showed equal/greater bactericidal activity but for 3d showing lesser activity against E.coli and 3c against GFC.