SOLID PHASE SYNTHESIS OF SUBSTITUTED 1,5-BENZODIAZEPINE-2-ONE AND 1,5-BENZOTHIAZEPINE-2-ONE

摘要

A solid phase synthetic method for making substituted 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one. The method is useful for synthesis of large numbers of compounds through automated parallel synthesis or combinatorial library generation and is thus important to rapid discovery or new therapeutic agents containing the base structure of 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one.