synthesis of isoxazolylpyrazolo[3,4-d]thiazoles and isoxazolylthiazoles and their antibacterial and antifungal activity.

摘要

Substtuted methyl/phenyl-[3-(3-mehtyl-5-styryl-isoxazol-4-yl)-4-phenyl-3H-thiazol-2-ylidene]amines 6,substituted-methyl/phenyl-[3-(3-mehtyl-5-styryl-isoxazol-4-yl)-thiazolidin-2-ylidene]-amines 7 and substiutted 2-methyl/phenylimino-methyl/phenyl-[3-(3-mehtyl-5-styryl-isoxazol-4-yl)-thioureas 2 with phenacyl bromide,1,2-dichloroethane and chloroacetic acid respectively.Condensaton of 3 with aromatic aldehydes or interaction f 2 with ethyl chloroacetate and aromatic aldehydes in the presence of pyridine and piperidine in a single step,gives substituted-5-arylidene-2-mehtyl/phenylimino-[3-(3-mehtyl-5-styryl-isoxazol-4-yl)-thiazolidin-4-ones 4,which are then cyclised t subsitutted [2-(2,4-dinitrophenyl)-6-(3-mehtyl-5-styryl-isoxazol-4yl)-3-aryl-2,3,3a,6-6-tetrahydro-pyrazolo[3,4-d]thiazol-5-ylidene]methyl/phenyl-amines 5 by reaction with 2,4-dinitrophenyl hydrazine in the presence of anhyd.sodium acetate.All the compounds have een evaluated for their antibacterial and antifungal activity.