Synthesis of pyrazole imines and azetidinone compounds using conventional and microwave technique and studies of their antibacterial activity

摘要

A series of compounds 4-[spiro-{1'-(4"-methylphenyl)-3'-methyl)-pyrazole]-3-chloro-l-(substitutedbenzothiazole)-2-azetidinone 4a-j have been prepared by the reaction of l-(4'-methylphenyl)-3-methyl-5-(2"-iminosubstitutedbenzo-thiazole)pyrazoles 3a-j with chloroacety! chloride in the presence of triethylamine.The pyrazole derivatives 3a-j have been prepared by the condensation of substituted 2-aminobenzothiazole 1 with l-(4'-methylphenyl)-3-methyl-5-pyrazolone 2.Both the reactions have been carried out by conventional and microwave methods.The synthesized compounds are screened for their antibacterial activity against Staphylococcus aureus,Bacillus subtilis,Escherichia coli and Salmonella typhi.