IMPROVED SYNTHESIS AND CYTOTOXIC STUDIES OF IMINE COMPOUNDS

摘要

The present innovation is focused on novel synthetic methods for preparing cytotoxic imine compounds and their derivatives represented by Structural Formula (I). Particularly, the present discovery relates to a process for the preparation of the cytotoxic imine compounds of the formula (I). R3 (I) wherein Rl and R2 are hydrogen, halogen, lower alky! (cl-4), lower alkyloxy (cl-c4), R3 is hydrogen, hydroxyl, R4 is hydrogen, hydroxy, or a pharmaceutically acceptable salt thereof. The said compounds are having cytotoxic properties represent inclusively all of the possible optical and geometrical isomers due to carbon and carbon-nitrogen double bond.