Novel barbituric acid derivatives of formula (I) wherein "—" represents a bond or no bond; Gr represents a group of formulae selected from wherein R1 and R2 are independently selected from hydrogen, halogen, hydroxy, lower alkyloxy, lower alkyl (C1-C4), substituted or unsubstituted aryloxy, aralkoxy; heteroaryloxy, heteroaralkoxy, cycloalkyloxy, cycloalkoxy; ii) indole benzenesulphonyl derivative of formula wherein R4, R5, R6 and R7 are independently selected from hydrogen, halogen, hydroxyl, cyano, nitro, amino, amido, thio, C2-C5 lower alkyl, lower alkylo"xy, lower alkanoyloxy, lower akanoyl; or its pharmaceutically acceptable salts, solvates, polymorphs, tautomers, optical and geometric isomers thereof, and one or more pharmaceutically acceptable carriers for the treatment of renal cancer.
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