Synthesis, Crystal Structure and Cytotoxic Activity of a New N-Vinyl-1H-dibenzoa,ccarbazole Derivative of the Dehydroabietic Acid

摘要

The title compound(C29H33NO2,3)was synthesized and structurally characterized by elemental analysis,IR,MS,1H-and13C-NMR and single-crystal X-ray diffraction.The crystal is of monoclinic system,space group P21with a=14.428(3),b=7.3440(15),c=22.768(5),β=95.17(3),V=2402.7(8)3,Z=4,Mr=427.56,Dc=1.182 g/cm3,F(000)=920,λ(MoKα)=0.71073,μ=0.073 mm-1,the final R=0.0670 and wR=0.1002 for 2437 reflections with I>2σ(I).Two crystallographically independent molecules with different conformations co-exist in the structure.The crystal structure is stabilized by intermolecular C Hπinteractions which make the molecules stack along the b axis.In addition,the preliminary cytotoxic assay showed that the title compound exhibited moderate inhibitory activity against KB and SW1116 cells.