Synthesis and antiinflammatory activity of some 3-(2-thiazolyl)-1,2-benzisothiazoles

摘要

Four types of benzisothiazole derivatives, 3-(4-alkyl/aryl-2-thiazolyl)/1,2-benzisothiazoles 1a-f 3-(4-aryl-5-carboxymethyl-2-thiazolyl)-1,2-benzisothiazoles 2, 3-(4-carboxylmethyl-2-thiazolyl)-1,2-benzisothiazole 3 and 3-(5-acetyl-4-methyl-2-thiazolyl)-1,2-benzisothiazole 1g have been synthesized as potential antiinflammatory agents. All the target compounds and some selected intermediates have been assayed for their antiinflammatory activity. some of these compounds posses excellent level of antiinflammatory activity.