Absorbance Correction H-Point Standard Addition Method for Simultaneous Spectrophotometry Determination of Ramipril, Hydrochlorothiazide and Telmisartan in Tablets

摘要

Simultaneous spectrophotometric method described for the determination of Ramipril, Hydrochlorothiazide and Telmisartan in tablets using absorbance correction - H-Point Standard addition method (HPSAM). A simple and novel method absorbance correction - HPSAM is reported for simultaneous estimation of three drugs using UV-visible spectrophotometry without any prior separation of samples. The linear range was 0.8 - 3 μg/mL for Ramipril, Hydrocholrothiazide and Telmisartan. The relative standard deviation (RSD) for the simultaneous determination of 2 μg/mL of Ramipril, hydrochlorothiazide and Telmisartan by applying HPSAM was 0.373, 1.176 and 1.296 respectively. The reported methods HPSAM can be claimed as green analytical chemistry as it does not involve the use of organic solvents and hence can be utilized for the routine analysis of these drugs from tablets.