Nature of the Main Contaminant in the Drug Primaquine Diphosphate:GC-MS Analysis

摘要

In the present work,GC-MS was used to provide evidence on fragmentation differences between primaquine and quinocide.Primaquine and quinocide are readily separated by GC.Both substances give visible M~+ molecular ion 259 m/z.The base peak in the mass spectrum of primaquine was found to be at m/z 201,in the mass spectrum of the positional-isomer quinocide the base peak was found to be at m/z 187.Two detailed MS fragmentation schemes for primaquine and quinocide are provided which can help to identify primaquine-like derivatives.Using GC-MS,it is possible to recognize with high confidence the positional-isomer contaminant in gas chromatograms of the antimalaria drug primaquine without a standard substance as reference.