Synthesis, Spectral Studies, Antimicrobial Activity and Crystal Structures of Phosphaza-Lariat Ethers

摘要

Phosphaza-lariat ethers, which are known as 2,2-[4,4'-(2,2'-oxybis(efhane-2,1-diyl)bis(oxy))dianilino]-4,4,6,6-tetrachlorocyclo-2λ~5,4λ~5,6λ~5-triphosphazatriene(spiro) (1), 2,2-[4,4'-(2,2,-(ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(oxy)dianilino]-4,4,6,6-tetrachlorocyclo-2λ~5,4λ~5,6λ~5-triphosphazatriene(spiro) (2) and 2,2-[4,4'-(2,2'-(ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(oxy)dianilino]-4,4-bis(tert- butylamino)-6,6-dichlorocyclo-22λ~5,4λ~5,6λ~5-triphosphazatriene (3) have been synthesized. The structures of the compounds (1, 2 and 3) are characterized by elemental analysis, IR, ~1H, ~(13)C, ~(31)P NMR and mass spectroscopic techniques. The antimicrobial activities of the compounds have been screened in vitro against the organisms. The structures of the compounds 1, 2 and 3 have also been examined by means of cyrstallographically. The compounds 1,2 and 3 crystallize in the orthorhombic space group Pbca, hexagonal space group P4_32_12 and tetragonal space group P4_2, respectively. They have unit cell parameters: a = 15.607(1), 10.6723(2) and 26.0308(9), b = 15.667(2), 10.6723(2) and 26.0308(9), c = 19.481(3), 23.3633(6) and 10.6033(4) A, V = 4763.4(1), 2661.03(1) and 7184.8(4) A~3, D_x = 1.570, 3.031 and 1.258 g cm~(-3) and Z = 8, 8 and 8, respectively.