Derivative Spectrophotometric Determination of Moclobemide in Pharmaceutical Formulations

摘要

A first derivative UV spectroscopic method was developed for determination of moclobemide in the tablet dosage form.The first derivative spectrum recorded between 200 and 300 nm and a zero-crossing technique for first derivative measurement at 225 nm was selected.The linear concentration ranges were 2-16 mu g/mL,r = 0.9994,n = 5).Between days CV % = 2.8,within day CV % = 2.1,analytical recovery close to 98.37-101.08 % shows the suitability of the method for determination in quality control.