Utility of Silver Nanoparticles as Coloring Sensor for Determination of Levofloxacin in its pure form and Pharmaceutical Formulations Using Spectrophotometric Technique

摘要

This study included the use of silver nano-particles (AgNPs) as colorimetric sensors for determining levofloxacin drug, that is one of fluoroquinolone family drug. The interference between levofloxacin drug and Ag-NPs produces new peaks measured in 507, 435 nm for Ag-NPsI and Ag-NPsII respectively. With regard to optimized conditions, certain perfect linear relationships (R~2=0.9991, 0.9855) have been acquired, in range ( 1-24), (1-12) μg/mL for Ag-NPsI and Ag-NPsII.The examined method's analytical performance has been audited, also the results have been acceptable, the impact of pharmacological action related drugs was studied and no interferences were showed. Several pharmaceutical dosage forms that containing levofloxacin have been effectively examined via studied approach with optimum degree of precision and accuracy, such approach could be environmentally safe since water is considered as the reaction solvent that might be the major considerable green solvent and doesn't need exhausting extraction or various treatment approaches.