Correlation of KI-67/MIB-1 in the Papillary Macro and Micro-carcinomas of the Thyroid Gland with the Prognosis of the Patients

摘要

The Papillary Thyroid Carcinoma (PTC) has the ability to show an aggressive clinical course and regional lymph node metastasis. This study was conducted to assess the Ki-67 labeling index (Ki-67.LI) as a prognostic factor to identify a high risk groupof the macro- and micro PTC to elucidate this issue. All 98 patients with the thyroid mass that underwent thyroidectomy enrolled in this study, then people were divided into two equal groups of case (PTC) and control (Benign thyroid lesions). We evaluated the ki-67.LI in their primary lesions and revealed its relationship with the various features of prognostic variables. The patients, who were followed-up during 24 months and recurrence and distant metastasis was proved. The ki-67.LI had statisticallysignificant correlation with the tumor size (p = 0.003), the vascular invasion and regional lymphatic involvement (p<0.001). An extra thyroid tissue invasion and extensive tumor necrosis were detected, with the high LI (p<0.001). The tumor multifocalitywas correlated with the LI>2.8% (p = 0.004). Among the remaining with the LI >2.8%, one patient with the Papillary Thyroid Micro Carcinoma (PTMC) and three patients with the Papillary Thyroid Carcinoma (PTC) were with the recurrence after the surgery. The ki-67.LI revealed a close correlation with the vascular-lymphatic invasion, the nodal metastasis, extra-thyroid extension and an extension of the necrosis and the infiltrative tumor borders. An evaluation of the ki-67 could be helpful to detect the high risk patient especially for the patient with papillary thyroid micro carcinoma.