首页> 外国专利> Method for detection of in vitro thyroid cancer in a patient, the method of in vitro differentiation between thyroid cancer and thyroid normal tissue or benign lesions of the thyroid.The use of a set of genes, a method of obtaining data for directing the treatment of thyroid cancer.Laboratory kit and device for classifying a biological sample of thyroid gland as malignant or benign

Method for detection of in vitro thyroid cancer in a patient, the method of in vitro differentiation between thyroid cancer and thyroid normal tissue or benign lesions of the thyroid.The use of a set of genes, a method of obtaining data for directing the treatment of thyroid cancer.Laboratory kit and device for classifying a biological sample of thyroid gland as malignant or benign

机译：检测患者体外甲状腺癌的方法，在甲状腺癌与甲状腺正常组织或甲状腺良性病变之间进行体外分化的方法。使用一组基因，一种获取数据的方法，用于指导治疗甲状腺癌。用于将甲状腺的生物学样本分类为恶性或良性的实验室套件和设备

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Method for detection of in vitro thyroid cancer in a patient, the method of in vitro differentiation between thyroid cancer and thyroid normal tissue or benign lesions of the thyroid.The use of a set of genes, a method of obtaining data for directing the treatment of thyroid cancer.Laboratory kit and device for classifying a biological sample of thyroid gland as malignant or benign.The present invention relates, in general, an in vitro method for detection of thyroid cancer in a patient.As a method of in vitro differentiation of cancer of thyroid benign lesions or normal thyroid tissue, and some other aspects relating to such methods.What is the use of a set of genes, a method of obtaining data for directing the treatment of thyroid cancer.Laboratory kit and device for classifying a biological sample of thyroid gland as malignant or benign.

机译：检测患者体外甲状腺癌的方法，在甲状腺癌与甲状腺正常组织或甲状腺良性病变之间进行体外分化的方法。使用一组基因，一种获取数据的方法，用于指导治疗用于将甲状腺的生物学样品分类为恶性或良性的实验室试剂盒和装置。总的来说，本发明涉及一种在患者中检测甲状腺癌的体外方法。甲状腺良性病变或正常甲状腺组织以及与此类方法有关的其他方面。一组基因的用途是什么，一种获得指导甲状腺癌治疗的数据的方法。用于对生物样品进行分类的实验室套件和设备甲状腺为恶性或良性。

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公开/公告号BR102015015096A2

专利类型
公开/公告日2018-10-16

原文格式PDF
申请/专利权人 FUNDAÇÃO ANTONIO PRUDENTE;UNIVERSIDADE ESTADUAL PAULISTA JULIO DE MESQUITA FILHO;
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申请/专利号BR20151015096
发明设计人 LUIZ PAULO KOWALSKI;MATEUS CAMARGO BARROS FILHO;SILVIA REGINA ROGATTO;
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申请日2015-06-23
分类号C12N15/11;C12Q1/68;
国家 BR
入库时间 2022-08-21 12:54:06

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2. Difference in CT texture analysis parameter of benign and malignant thyroid nodules and its correlation with the malignant biological behaviors of cancer cells [J] . Jia-Xue Qi, Xiao-Lin Yuan, Wen-Ze Wu 海南医科大学学报(英文版) . 2018,第014期

3. The correlation between the ultrasonic elastic strain ratio of thyroid cancer and the malignant biological characteristics of cancer cells in the lesions [J] . Li Ma, Rong Zhou, Yun-Zhu Li 海南医科大学学报（英文版） . 2017,第008期

4. The correlation between the ultrasonic elastic strain ratio of thyroid cancer and the malignant biological characteristics of cancer cells in the lesions [J] . Li Ma, Rong Zhou, Yun-Zhu Li 海南医科大学学报(英文版) . 2017,第008期

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6. Ultrasound Real-Time Tissue Elastography Improves the Diagnostic Performance of the ACR Thyroid Imaging Reporting and Data System in Differentiating Malignant from Benign Thyroid Nodules: A Summary of 1525 Thyroid Nodules [J] . Shufang Pei, Bin Zhang, Shuzhen Cong, International journal of endocrinology . 2020,第2期

7. I-131 biokinetics of remnant normal thyroid tissue and residual thyroid cancer in patients with differentiated thyroid cancer: comparison between recombinant human TSH administration and thyroid hormone withdrawal [J] . Chae Moon Hong, Choon-Young Kim, Seung Hyun Son, Annals of nuclear medicine . 2017,第8期

8. Quantitative analysis of collagen change between normal and cancerous thyroid tissues based on SHG method [C] . Xiwen Chen, Zufang Huang, Gangqin Xi, Photonics and imaging in biology and medicine . 2011

9. Ultrasound Real-Time Tissue Elastography Improves the Diagnostic Performance of the ACR Thyroid Imaging Reporting and Data System in Differentiating Malignant from Benign Thyroid Nodules: A Summary of 1525 Thyroid Nodules [O] . Shufang Pei, Bin Zhang, Shuzhen Cong, 2020

10. Poster session 2Morphogenetic mechanisms290MiR-133 regulates retinoic acid pathway during early cardiac chamber specification291Bmp2 regulates atrial differentiation through miR-130 during early heart looping formationDevelopmental genetics294Association of deletion allele of insertion/deletion polymorphism in alpha 2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus295Association of G1359A polymorphism of the endocannabinoid type 1 receptor (CNR1) with coronary artery disease (CAD) with type 2 diabetes mellitusCell growth, differentiation and stem cells - Vascular298Gamma-secretase inhibitor prevents proliferation and migration of ductus arteriosus smooth muscle cells: a role of Notch signaling in postnatal closure of ductus arteriosus299Mesenchymal stromal-like cells (MLCs) derived from induced pluripotent stem (iPS) cells: a promising therapeutic option to promote neovascularization300Sonic Hedgehog promotes mesenchymal stem cell differentiation to vascular smooth muscle cells in cardiovacsular disease301Proinflammatory cytokine secretion and epigenetic modification in endothelial cells treated LPS-GinfivalisCell death and apoptosis - Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - Heart336Novel myosin activator, JSH compounds, increased myocardial contractility without chronotropic effect in ratsExtracellular matrix and fibrosis - Vascular339Ablation of Toll-like receptor 9 causes cardiac rupture after myocardial infarction by attenuating proliferation and differentiation of cardiac fibroblasts340Altered vascular remodeling in the mouse hind limb ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic angiogenesis for coronary total occlusion344Nrf2 drives angiogenesis in transcription-independent manner: new function of the master regulator of oxidative stress response345Angiogenic gene therapy, despite efficient vascular growth, is not able to improve muscle function in normoxic or chronically ischemic rabbit hindlimbs -role of capillary arterialization and shunting346Effect of PAR-1 inhibition on collateral vessel growth in the murine hind limb model347Quaking is a key regulator of endothelial cell differentiation, neovascularization and angiogenesis348"Emerging angiogenesis" in the chick chorioallantoic membrane (CAM). 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