Synthesis and Antimicrobial Screening of Some Novel Pyrazoline Derivatives

摘要

A new series of methyl-4-(4,5-dihydro-5-[(Z)phenyl]-1H-pyrazol-3-yl)-2-rnethylbenzohydrazide were synthesized by cyclisization of chatcones, methyl 4-((E)-3-((Z)phenyl)acryloyl)-2-methylbenzoate with hydrazine hydrate in presence of basic media. The chalcones were synthesized starting from 4-acetyI-2-methylbenzoic acid in 2 step. The structures of the synthesized compounds have been established on the basis of physical and spectral data and are screened for antimicrobial activity. Some of them exhibited significant activity.