Synthesis And Antimicrobial Screening of Novel Chalcone and Pyrazoline Molecules Bearing 4-(difluoromethoxy)-3-hydroxybenzaldehyde Nucleus.

摘要

ABSTRACT A series of novel Chalcones 2a-i and Pyrazolines 3a-i have been synthesized and evaluated their antibacterial and antifungal activity. The Pyrazolines 3a-i have been synthesized by reaction of various Chalcones 2a-i with Isoniazide in presence of glacial acetic acid. The Chalcones of 2a-i were prepared by the reaction of 4(difluoromethoxy)-3-hydroxybenzaldehyde with substitued acetophenone in aqueous sodium hydroxide using ethanol as a solvent. The structures of the newly synthesized c.