Pourquoi et comment utiliser les anticoagulants oraux directs (AOD) dans la maladie thromboembolique veineuse (MTEV) ? Why and how to use the Direct Oral Anticoagulants (DOA) for the treatment of venous thromboembolic events?

摘要

Direct Oral Anticoagulants have demonstrated their efficacy in the treatment and prevention or recurrences of venous thromboembolic events with a similar or reduced bleeding risk compared to the reference (low molecular weight heparin and vitamin K antagonist therapy). They are both simple to use because of no need for dose adjustment nor biological monitoring of hemostasis, and complex because they follow very different prescription patterns. They are not recommended in all situations, especially in case of severe renal insufficiency, pregnancy or cancer. The choice of the anticoagulant drug depends on the prescriber and on the patient and has to be decided using a personalized approach. ? 2016 Elsevier Masson SAS. All rights reserved