European data on stem cell mobilization with plerixafor in non-Hodgkin's lymphoma, Hodgkin's lymphoma and multiple myeloma patients. A subgroup analysis of the European Consortium of stem cell mobilization

摘要

The effectiveness of the novel hematopoietic stem cell mobilizing agent plerixafor was evaluated in nationwide compassionate use programs in 13 European countries. A total of 580 poor mobilizers with non-Hodgkin's lymphoma (NHL), Hodgkin's lymphoma (HL) and multiple myeloma (MM) were enrolled. All patients received plerixafor plus granulocyte CSF with or without chemotherapy. Overall, the collection yield was significantly higher in MM patients (2.0 × 10 6 CD34 cells/kg: 81.6%; 5.0 × 10 6 CD34 cells/kg: 32.0%) than in NHL patients (2.0 × 10 6 CD34 cells/kg: 64.8%; 5.0 × 10 6 CD34 cells/kg: 12.6%; P0.0001) and also significantly higher in HL patients (2.0 × 10 6 CD34 cells/kg: 81.5%; 5.0 × 10 6 CD34 cells/kg: 22.2%) than in NHL patients (P0.013). In a subgroup analysis, there were no significant differences in mobilization success comparing patients with diffuse large B-cell lymphoma, follicular lymphoma and mantle cell lymphoma. Our data emphasize the role of plerixafor in poor mobilizers, but further strategies to improve the apheresis yield especially in patients with NHL are required.