Intramolecular Palladium-Catalyzed Direct Arylation vs. Heck Reactions: Synthesis of Pyrroloisoquinolines and Isoindoles

摘要

The competition between C-H activation and Heck reactions has been studied on 2-alkenyl-substituted o-iodobenzylpyrroles. The reaction can be switched from the alkene to the pyrrole nucleus by choosing the adequate catalytic system, regardless of the nature of the substituent on the alkene, ob- taining excellent yields of pyrrolo[1,2-b]isoquinolines or pyrrolo[2,1-a]isoindoles.