A novel antiphospholipid antibody agent?

摘要

In this issue of Blood, Rand and colleagues have shown that in vitro hydroxychloro-quine can reverse antiphospholipid antibody-mediated disruption of the annexin VA crystalline shield that protects phospholipid bilayers from taking part in coagulation reactions. The protective effect of hydroxychloroquine against antiphospholipid antibody-induced damage was seen on both cultured endothelial cells and a syncytialized trophoblast cell line.