首页> 外文期刊>Health Physics: Official Journal of the Health Physics Society >Developments in Biodosimetry Methods for Triage With a Focus on X-band Electron Paramagnetic Resonance In Vivo Fingernail Dosimetry
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Developments in Biodosimetry Methods for Triage With a Focus on X-band Electron Paramagnetic Resonance In Vivo Fingernail Dosimetry

机译:发展Biodosimetry分类的方法专注于x波段电子顺共振体内指甲剂量测定法

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摘要

Instrumentation and application methodologies for rapidly and accurately estimating individual ionizing radiation dose are needed for on-site triage in a radiological/nuclear event. One such methodology is an in vivo X-band, electron paramagnetic resonance, physically based dosimetry method to directly measure the radiation-induced signal in fingernails. The primary components under development are key instrument features, such as resonators with unique geometries that allow for large sampling volumes but limit radiation-induced signal measurements to the nail plate, and methodological approaches for addressing interfering signals in the nail and for calibrating dose from radiation-induced signal measurements. One resonator development highlighted here is a surface resonator array designed to reduce signal detection losses due to the soft tissues underlying the nail plate. Several surface resonator array geometries, along with ergonomic features to stabilize fingernail placement, have been tested in tissue-equivalent nail models and in vivo nail measurements of healthy volunteers using simulated radiation-induced signals in their fingernails. These studies demonstrated radiation-induced signal detection sensitivities and quantitation limits approaching the clinically relevant range of 10 Gy. Studies of the capabilities of the current instrument suggest that a reduction in the variability in radiation-induced signal measurements can be obtained with refinements to the surface resonator array and ergonomic features of the human interface to the instrument. Additional studies are required before the quantitative limits of the assay can be determined for triage decisions in a field application of dosimetry. These include expanded in vivo nail studies and associated ex vivo nail studies to provide informed approaches to accommodate for a potential interfering native signal in the nails when calculating the radiation-induced signal from the nail plate spectral measurements and to provide a method for calibrating dose estimates from the radiation-induced signal measurements based on quantifying experiments in patients undergoing total-body irradiation or total-skin electron therapy.
机译:工具和应用程序的方法迅速而准确地评估个体电离辐射剂量需要现场诊断放射学/核事件。方法论是一个体内x波段,电子顺磁共振、身体的基础剂量测定法直接测量的方法辐射诱导信号指甲。主要组件在开发是关键仪器功能,如谐振器独特的几何图形,让大型抽样卷但限制辐射诱导的信号钉板测量,方法论的方法解决在指甲和干扰信号校准剂量辐射诱导的信号测量。强调这是一个表面谐振器阵列旨在减少信号检测损失软组织的钉板。几面谐振器阵列的几何图形,以及人体工程学特性稳定指甲位置,在组织等效测试指甲甲的测量模型和体内健康的志愿者使用模拟辐射诱导信号的指甲。这些研究证明了辐射诱导信号检测敏感性和定量限制接近临床相关的范围10 Gy。当前仪器建议减少辐射诱导信号的变化测量可以获得与细化谐振器阵列表面和人体工程学人机界面的特性乐器。在定量分析的局限性确定分类决策领域剂量测定法的应用。体内钉研究和相关体外钉研究提供明智的方法容纳一个潜在的干扰当计算信号的指甲从钉板辐射诱导的信号光谱测量,并提供一种方法校准剂量估计辐射诱导信号测量的基础上在患者接受量化实验全身照射或总表面电子治疗。

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