Beta 2 glycoprotein I is a substrate of thiol oxidoreductases.

摘要

Beta 2 glycoprotein I (beta2GPI) is an abundant plasma protein recognized as the major autoantigen in the antiphospholipid syndrome. Although the crystal structure of beta2GPI has been resolved,1'2 its normal function remains unknown. We have been intrigued by the presence of a C-terminal cysteine (Cys326), which forms a loop-back disulfide link in the fifth domain of beta2GPI. In the current study we examined p2GPI's potential to participate in thiol exchange reactions with the thiol oxidoreductases thiore-doxin-1 (TRX-1) and protein disulfide isomerase (PDI).