No influence of gene polymorphism of LCT (C13910T) on transplantation outcomes in acute myeloid leukemia patients who received transplantations from HLA-identical sibling donors.

摘要

Recently, Hauser and coworkers reported that a single nucleo-tide polymorphism (SNP) of the lactase persistence gene (LCT) at position 13910 of the donor influenced patient outcome after allogeneic hematopoietic stem cell transplantation.1 They reported in a study of 111 recipients/donor pairs that median overall survival (OS), death in remission, and relapse rate were significantly improved when recipients received transplantations from donors homozygous for CC at 13910 in the LCT gene. They argued that lactose malabsorption changes the composition of colonic microflora, which could be caused by genetic polymorphisms leading to nonpersistence of lactase phlorizin hydrolase, a beta-galactosidase, expressed exclusively in the small intestine. Changes in the composition of colonic microflora and in the gut-associated immune system might influence the outcome of transplantation as reported for genetic variants of NOD2/CARD15 genes, which are associated with an increase in incidence and severity of acute graft-versus-host disease (GVHD) after transplantation.