Homologous recombination of wild-type JAK2, a novel early step in the development of myeloproliferative neoplasm.

摘要

Transformation of hematopoietic cells depends on the acquisition of genetic events leading to cytokine independence, typically associated with acquisition of an autocrine cytokine loop or/and increased expression or/and mutation of JAK genes. Rearrangement of the JAK2 gene, which presumably alters JAK2 transcription, is reported in hematopoietic cells. Murine models of myelopro-liferative neoplasms (MPN) demonstrated that the polycythemia vera (PV) phenotype requires the combination of high expression and activation of Jak2.