The Pattern of Expression and Role of TrijodothyronIne (T3) Receptors and Type I.5'-Deiodinase in Breast Carcinomas, Benign Breast Diseases, Lactational Change,and Normal Breast Epithelium

摘要

Aim: To study the pattern of expression of triiodothyronine (T3) receptors and type I 5'-deibdinase in various breast pathologies comparing malignant and nonmalignant epithelia that include lactational change.Methods and Results: A retrospective study was performed on formalin-fixed, paraffin-embedded archival material from 146 cases of carcinomas, normal breast tissue, breast tissue showing lactational change, and benign breast lesions. Archive tissue blocks were selected and sections were cut for im-munohistochemistry to study the expression of thyroid hormone receptor alpha-1 (THR-alpha1) in the cytoplasm and nuclei of cells in tissues under study. Thick sections were cut for type I 5'-de-iodinase evaluation using reverse transcriptional PCR.