Dabigatran - Neurosurgical anathema?

摘要

To the Editor: We welcome the articles by Eikelboom and Hankey1 and Attia and Pearce about the use of dabigatran as an alternative to warfarin for prevention of embolic stroke. While it is encouraging that new, effective, anticoagulant agents have been added to the anticoagulant pharmacopoeia, we wish to raise specific concerns about the management of intracranial haemorrhage in patients treated with dabigatran. While both the incidence and mortality of intracranial haemorrhage have been reported to be lower in patients taking dabigatran in the RE-LY trial, no mention was made as to operative management of such haematomas should they occur.