摘要：Acromegaly is invariably caused by a GH secreting pituitary tumour and results in significant patient morbidity and premature cardiovascular mortality．Treatment options first and foremost should reverse the disabling symptoms (headache，sweating，tiredness，paraesthesia，arthralgia,snoring) and address the pituitary tumour itself，ideally with total excision and prevention of recurrence．The last 10 years has also seen an evidence base for the biochemical follow-up and "cure"of patients with Acromegaly，with a series of retrospective follow-up studies showing normalization of mortal ity rates if GH can be reduced to<5 mU／L(2．5 ?g／L)．
