首页> 外文期刊>Climacteric: the journal of the International Menopause Society >The effect of estrogen plus progestin treatment on sleep: a randomized, placebo-controlled, double-blind trial in premenopausal and late postmenopausal women.
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The effect of estrogen plus progestin treatment on sleep: a randomized, placebo-controlled, double-blind trial in premenopausal and late postmenopausal women.

机译:雌激素加孕激素治疗对睡眠的影响:绝经前和绝经后晚期妇女的一项随机,安慰剂对照,双盲试验。

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OBJECTIVE: In this prospective randomized, placebo-controlled and double-blind study, the objective was to investigate the effects of estrogen-progestin treatment (EPT) on sleep in pre- and postmenopausal women. DESIGN: Seventeen premenopausal (aged 45-51 years) and 18 postmenopausal (aged 58-70 years) women were studied in a sleep laboratory for two nights (one night for adaptation and one study night) before and after 6 months of treatment with EPT or placebo. During the treatment period, premenopausal women received cyclic EPT or placebo and the postmenopausal women continuous EPT or placebo. Polysomnography and questionnaires were used to evaluate sleep and well-being. RESULTS: At the end of the treatment period, premenopausal women receiving EPT had more awakenings from stage 1 sleep (p = 0.047) and postmenopausal women with EPT had a greater total number of awakenings (p = 0.031) than the corresponding placebo group. Further, sleepiness decreased less in the premenopausal EPT group than in the placebo group (p = 0.031). In postmenopausal women, EPT decreased and placebo slightly increased slow wave activity during the second non-rapid eye movement sleep episode (p = 0.046). CONCLUSIONS: In premenopausal and late postmenopausal women, EPT had only random and marginal effects on sleep. Although the limited findings were mostly unfavorable for EPT, one cannot conclude that EPT deteriorates sleep. Further, neither middle-aged cycling premenopausal women nor older postmenopausal women benefit from estrogen-progestin treatment in terms of their sleep quality.
机译:目的:在这项前瞻性随机,安慰剂对照和双盲研究中,目的是研究雌激素-孕激素治疗(EPT)对绝经前后妇女睡眠的影响。设计:在接受EPT治疗6个月之前和之后,在睡眠实验室对17名绝经前(45-51岁)和18名绝经后(58-70岁)的妇女进行了两个晚上(适应性夜晚和一个研究夜)的研究。或安慰剂。在治疗期间,绝经前妇女接受周期性EPT或安慰剂治疗,绝经后妇女持续接受EPT或安慰剂治疗。多导睡眠监测仪和问卷用于评估睡眠和幸福感。结果:在治疗期结束时,接受EPT的绝经前妇女从1期睡眠后的觉醒次数更多(p = 0.047),而接受EPT的绝经后妇女的觉醒总数比相应的安慰剂组要多(p = 0.031)。此外,绝经前EPT组的嗜睡减少少于安慰剂组(p = 0.031)。在绝经后妇女的第二次非快速眼动睡眠事件中,EPT降低,安慰剂略微增加了慢波活动(p = 0.046)。结论:在绝经前和绝经后晚期妇女中,EPT仅对睡眠产生随机和边际影响。尽管有限的发现大部分对EPT不利,但不能得出EPT会恶化睡眠的结论。此外,绝经前的中年女性和绝经后的老年女性都没有从睡眠质量方面受益于雌激素-孕激素治疗。

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