Role of 18F-FDG PET-CT for evaluating the response to reducedintensity conditioning allogeneic transplant in heavily pre-treated patients with chronic lymphocytic leukemia: Preliminary results in nine patients

摘要

Objective The aim of our preliminary study was to evaluate the potential role of 18F-FDG PET-CT in monitoring response to reduced-intensity conditioning (RIC) transplant in a small series of chronic lymphocytic leukemia (CLL) patients and to compare the results with those obtained by standard criteria. Methods We retrospectively analyzed 9 consecutive refractory/relapsed CLL patients, who underwent RIC transplant fromMarch 2004 untilMay 2009. PET-CTwas planned at 6-8 months after transplant to assess response and at a mean of 6 months during follow-up. The mean long-term follow-up period was 38 months (range 12-74 months, median 29 months). Results The first PET-CT showed abnormal 18F-FDG uptake in five patients, while by standard criteria eight patients showed persistent disease. At the end of follow-up (mean 38 months), all four patients with previously negative scan were still PET negative and in complete remission by standard criteria. All five patients with previously positive scan were still PET positive: one patient died for disease progression and four are alive with disease. Conclusions Our preliminary data, although in a small series of CLL patients, suggest that the metabolic findings revealed at first PET-CT after transplant seem to predict the patient outcome and to assess the metabolic disease status earlier than clinical evaluation by standard criteria. PETCT performed during follow-up may be useful to early detect disease progression.