Influence of Hormonal Profile on Resting Metabolic Rate in Normal, Overweight and Obese Individuals

摘要

Aims: To investigate whether blood thyroid stimulating hormone (TSH), cortisol, insulin and glucose concentrations (plus glucose: insulin ratio; GIR) could improve the accuracy of resting metabolic rate (RMR) prediction in normal, overweight and obese persons. Methods: Predictive equations were developed and compared against indirect calorimetry measures for RMR in 217 weight-control clinic participants (n = 128 males and n = 89 females: similar to 24% normal weight, similar to 39% overweight and similar to 37% obese). Results: Using the common accuracy criteria of the proportion of predicted RMR within similar to 10% of measured RMR, our equations (using age, height, weight and gender, plus the blood factors, both independently and in combination) were accurate similar to 36-44% of the time, for the whole sample, and when separated by gender and weight class. Specifically, the addition of the blood hormone and glucose concentrations improved the accuracy of predicted RMR by only 1-8% (NS). Conclusions: Including blood TSH, cortisol, insulin, glucose and GIR into RMR prediction equations did not significantly improve estimation accuracy, which in any case only met a criterion of +/- 10% of the measured RMR +/- 40% of the time. Further work to refine the prediction of RMR is still needed, and at present, direct measurements should be made wherever possible. (C) 2015 S. Karger AG, Basel