A Highly Effective Phosphoramidite Ligand for Asymmetric Allylic Substitution

摘要

Asymmetric allylic substitution [Eq.(1)] is a potentially powerful method for creating chiral centers in readily available starting materials.Great efforts have been made to control the chemo-,regio-,and enantioselectivities of the reaction products.In contrast to other metals (Pd,Mo,and Ir,for example),copper allows harder nucleophiles,such as alkyl groups,to be used.Increasing interest is being shown in catalytic systems where the copper center is coordinated to a chiral ligand,such as with Grignard and organozinc reagents.