Rapid Synthesis of Ga-68-labeled macroaggregated human serum albumin (MAA) for routine application in perfusion imaging using PET/CT

摘要

Tc-99m-labeled MAA is commonly used for single photon emission computed tomography SPECT. In contrast, positron emission tomography/CT (PET/CT) delivers images with significantly higher resolution. The generator produced radionuclide Ga-68 is widely used for PET/CT imaging agents and Ga-68-labeled MAA represents an attractive alternative to Tc-99m-labeled MAA. We report a simple and rapid NaCl based labeling procedure for the labeling of MAA with Ga-68 using a commercially available MAA labeling kit for Tc-99m. The procedure delivers Ga-68-labeled MAA with a high specific activity and a high labeling efficiency (> 99%). The synthesis does not require a final step of separation or the use of organic solvents.