Stereoselective Synthesis of anti-β-Hydroxy-α-amino Acids through Dynamic Kinetic Resolution

摘要

β-Hydroxy-α-amino acids are valuable constituents of a variety of biologically active natural products and medicinally important compounds, and many approaches for their enantioselective synthesis have been reported. In connection with our ongoing research into the total synthesis of cyclodepsipeptides, papuamides, and polyoxypeptins with biologically interesting activities, we needed a new method for the preparation of a large amount of (2R,3R)-and (2S,3S)-3-hydroxyleucine bearing the skeleton of an anti-β-hydroxy-α-amino acid, with control of both relative and absolute configuration.