Stereoselective Synthesis of anti-β-Hydroxy-α-Amino Acids Using anti-Selective Asymmetric Hydrogenation

摘要

anti-β-Hydroxy-α-amino acids are efficiently synthesized from chirally labile α-amino-β-keto esters using ruthenium- and iridium-catalyzed asymmetric hydrogenation through dynamic kinetic resolution, which is capable of the stereocontrolled construction of two consecutive stereocenters at one reaction.