Catalytic, Highly Enantioselective, Direct Amination of beta-Ketoesters

摘要

Optically active alpha-amino acid derivatives are fundamental constituents of numerous natural products and of other highly valuable compounds of importance for our daily life. Many different approaches for the synthesis of optically active alpha-amino acids are available.~[1] However, the development of strereoselective transformations for the synthesis of optically active non-natural alpha-amino acid derivatives from simple and readily available starting compounds in the presence of a chiral catalyst is an ongoing challenge for chemists. The importance of these molecules has led to extensive development of synthetic methods that use catalytic enantioselective reactions. Ther majority of the procedures developed for the dformatio of optically active alpha-amino acid derivatives are C-C-bond-forming reactions and include catalytic enantioselective addition to imines using Strecker~[2] and Mannich~[3] reactions.