Highly Enantioselective Catalytic Carbon Dioxide Incorporation Reaction: Nickel-Catalyzed Asymmetric Carboxylative Cyclization of Bis-l,3-dienes

摘要

A Method for nickel-catalyzed asymmetric carbon dioxide (CO_2) incorporation via carbon-carbon bond formation was developed.In the presence of a catalytic amount of Ni(acac)_2 and (S)-MeO-MOP,various bis-l,3-dienes reacted with CO_2 (1 atm) and a diorganozinc reagent (Me_2Zn or Ph_2Zn) to afford cyclic carboxylic acids in good yields (71-100%) and with high enantioselectivities (90-96% ee).