Anion Relay Chemistry: Development of an Effective Diastereo-selective [3+2] Annulation Tactic Exploiting an Aldol/Brook Rearrangement/Cyclization Cascade

摘要

An effective [3+2] annulation tactic for the construction of diverse bicyclic compounds possessing highly functionalized cyclopentane rings has been developed employing soft ketone enolates as the initial nucleophile for anion relay chemistry (ARC). The protocol entails a highly diastereoselective aldol/Brook rearrangement/cyclization cascade.