Anion Relay Chemistry: Development of an Effective Diastereoselective 3+2 Annulation Tactic Exploiting an Aldol/Brook Rearrangement/Cyclization Cascade

摘要

An effective [3+2] annulation tactic for the construction of diverse bicyclic compounds possessing highly functionalized cyclopentane rings has been developed employing soft ketone enolates as the initial nucleophile for Anion-Relay-Chemistry (ARC). The protocol entails a highly diastereoselective Aldol/Brook rearrangement/cyclization cascade.