Novel anti-inflammatory mechanisms of N-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage

摘要

Ac-SDKP is an endogenous peptide released from its precursor (thymosin-p4) by proline oligopeptidase (9, 12). Ac-SDKP is a natural inhibitor of pluripotent hematopoietic stem cell proliferation (5) and is normally found in human plasma and circulating monocyte cells (2). Early on, Ac-SDKP was shown to originate from bone marrow (19), but it has recently been shown that in mice both Ac-SDKP and its precursor are ubiquitously distributed in tissues including the lung, kidney, and heart (31). Ac-SDKP is mainly hydrolyzed by angiotensin converting enzyme (ACE), and ACE inhibitors (ACEi) prevent its hydrolysis and raise its concentration in plasma four- to fivefold (2).