Glucocorticoid regulation of CD38 expression in human airway smooth muscle cells: role of dual specificity phosphatase 1

摘要

glucocorticotds are widely used as immunosuppressive and anti-inflammatory agents. Synthetic glucocorticoids are useful in the treatment of inflammatory diseases such as asthma, rheumatoid arthritis, Crohn's disease, and chronic allergic diseases. The anti-inflammatory effects of the glucocorticoids are mediated by at least two distinct mechanisms: 1) binding to the glucocorticoid response elements (GREs) within the promoter regions of genes as a transcription factor to activate transcription; and 2) as an inhibitor of transcription factors such as NF-kB and activator protein-1 (AP-1) through a protein-protein interaction known as transrepression.